[Viva] TreatmentUpdate 232

[Pegfrank]

Thanks for these Shelly. Very interesting.  love-peg
> On Aug 26, 2019, at 1:07 PM, shelly tognazzini <shetognazzini at gmail.com> wrote:
> 
> 
> 
> ---------- Forwarded message ---------
> From: CATIE <mailer at catie.ca <mailto:mailer at catie.ca>>
> Date: Mon, Aug 26, 2019 at 12:05 PM
> Subject: TreatmentUpdate 232
> To: <shetognazzini at gmail.com <mailto:shetognazzini at gmail.com>>
> 
> 
> Issue 232
> View this email in your browser <https://mailchi.mp/3d01099bdbfe/treatmentupdate-232?e=3006f90030>
> 
> HIV cure research
> Potential concern raised with CCR5 interference <https://catie.us16.list-manage.com/track/click?u=89abcbccf295c7b8d9a92cf09&id=0e98e33752&e=3006f90030>
> In rare cases some people are born with a genetic mutation called the delta-32 mutation, which makes them naturally resistant to most strains of HIV. Scientists from California and Denmark analysed data from a large database called the UK Biobank and found that the delta-32 mutation in people of British descent was associated with a 21% increased risk of death. The cause of death is unknown
>  
> Gene therapy—CRISPR starts to move forward against HIV <https://catie.us16.list-manage.com/track/click?u=89abcbccf295c7b8d9a92cf09&id=eb02a7d762&e=3006f90030>
> One approach to gene therapy that has much potential is called CRISPR (clustered regularly interspaced short palindromic repeats). Recently, scientists in the U.S. performed a series of complex and detailed experiments using a combination of CRISPR and nano-ART in HIV-infected mice.
>  
> Will gene therapy for HIV cause financial toxicity? <https://catie.us16.list-manage.com/track/click?u=89abcbccf295c7b8d9a92cf09&id=3d680d02d5&e=3006f90030>
> The technology of gene editing through CRISPR has the potential to clear human genes of the DNA needed by viruses such as HIV. Should this cutting-edge treatment one day be approved by regulatory agencies in Canada and other high-income countries, it is likely to be very expensive, as gene therapies for cancer are. The high price of medicines causes what some researchers refer to as “financial toxicity” for patients.
> 
> Inflammation
> Attention on inflammation also turns to fungi <https://catie.us16.list-manage.com/track/click?u=89abcbccf295c7b8d9a92cf09&id=82db83aba9&e=3006f90030>
> HIV is associated with excess activation of the immune system and excess general inflammation. The cause of this is not clear, but one theory is that HIV infection weakens the intestines, allowing microbes and/or proteins associated with these microbes to leak through the gut into the blood. Once in the blood, these microbes and/or their proteins circulate and contribute to excess immune activation and inflammation. Scientists in Montreal have performed experiments that strongly suggest that “fungal translocation” occurs in the gut of HIV-positive people
>  
> Future potential interventions against fungal translocation <https://catie.us16.list-manage.com/track/click?u=89abcbccf295c7b8d9a92cf09&id=fde560bc85&e=3006f90030>
> The problem of fungal translocation is not reduced by taking ART. Physician-scientist and fungus expert Martin Hoenigl, MD, from the University of California at San Diego suggests that different antifungal agents be tested for their potential to reduce excess HIV-related immune activation and inflammation. Although broad-spectrum antifungals may be considered for future studies of fungal translocation, Dr. Hoenigl notes that emerging antifungal drugs are likely “better tolerated and/or allow for once weekly [dosing].” Such antifungal drugs are currently in phase II or phase III clinical trials.
> 
>  <https://catie.us16.list-manage.com/track/click?u=89abcbccf295c7b8d9a92cf09&id=aef9b67da1&e=3006f90030>
>  <https://catie.us16.list-manage.com/track/click?u=89abcbccf295c7b8d9a92cf09&id=c866247104&e=3006f90030>
>  <https://catie.us16.list-manage.com/track/click?u=89abcbccf295c7b8d9a92cf09&id=03abcec844&e=3006f90030>
>  <https://catie.us16.list-manage.com/track/click?u=89abcbccf295c7b8d9a92cf09&id=776859519a&e=3006f90030>
>  <https://catie.us16.list-manage.com/track/click?u=89abcbccf295c7b8d9a92cf09&id=6826b2ae75&e=3006f90030>
>   <https://catie.us16.list-manage.com/track/click?u=89abcbccf295c7b8d9a92cf09&id=d40890234b&e=3006f90030>
> Our mailing address is:
> CATIE 555 Richmond St. West Suite 505 Toronto, On M5V 3B1 Canada <https://www.google.com/maps/search/555+Richmond+St.+West%0D%0ASuite+505%0D%0AToronto,+On+M5V+3B1%0D%0ACanada?entry=gmail&source=g>
> 
> Want to change how you receive these emails?
> You can update your preferences <https://catie.us16.list-manage.com/profile?u=89abcbccf295c7b8d9a92cf09&id=ae993f6577&e=3006f90030> or unsubscribe from this list <https://catie.us16.list-manage.com/unsubscribe?u=89abcbccf295c7b8d9a92cf09&id=ae993f6577&e=3006f90030&c=3d64bda2b9>.
> 
> Privacy <https://catie.us16.list-manage.com/track/click?u=89abcbccf295c7b8d9a92cf09&id=92206fcba0&e=3006f90030> | Disclaimer <https://catie.us16.list-manage.com/track/click?u=89abcbccf295c7b8d9a92cf09&id=4dbf84ece5&e=3006f90030> | Permission to reproduce <https://catie.us16.list-manage.com/track/click?u=89abcbccf295c7b8d9a92cf09&id=cea8511731&e=3006f90030> 
> _______________________________________________
> VIVA mailing list
> VIVA at lists.resist.ca
> https://lists.resist.ca/cgi-bin/mailman/listinfo/viva

- Peggy Frank

Now seeing the morning sun rise from 1103-139 Clarence St., Victoria, BC V8V2J1

“I have been and still am a seeker,
but I have ceased to question stars and books;
I have begun to listen to the teachings
My blood whispers to me.”
- Herman Hesse



-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://lists.resist.ca/pipermail/viva/attachments/20190828/485acc8e/attachment-0001.html>